The goal of the Spranger lab is to understand how a range of tumor cell-intrinsic, tissue-specific and environmental factors directly impact the interaction between the cancer and the immune system.

Dendritic cells within the tumor-immune microenvironment. We are interested understanding the contribution of dendritic cells and other antigen presenting cells to the local tumor-immune microenvironment.
Tumor-reactive T cell can mediate tumor control and are a predicative marker for immunotherapy efficacy. The Spranger lab is interested in understanding the factors mediating T cell exclusion from the tumor microenvironment.
Studying the tumor-immune microenvironment. The Spranger lab is interested in understanding the interactions between immune cells and tumor cells on local and system levels.